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Fanconi Syndrome – Symptoms, Causes, Treatment

What is Fanconi Syndrome ?

There is one specific condition or more likely, a disease that affects the proximal renal tubes of the kidney. This is bad since it generates some complications with the tubes’ functions such as reabsorbing amino acids, phosphate, bicarbonate, glucose, and uric acid. This condition instead, passes these substances into the urine where, we would not be able to benefit from their nutrients since they are excreted. This syndrome is more known as the Fanconi Syndrome or as some prefers to call it, the Renal Fanconi Syndrome.


The proximal tubule is the very first part of the tubule. Here, the fluids are being processed so that our body can benefit from them and some of them are very essential to our health. But, when that very specific tubule passes them on to urine where they will be excreted instead of processing them so that we can use them, imagine what problems it can cause.

The Fanconi syndrome may lead to several different complications if it is left untreated and ignored. Fanconi syndrome can give a person a Type 2 or also called a proximal renal tubular acidosis if there is a distinctive loss of bicarbonate which is done when a person is suffering from the Fanconi syndrome. The loss of other very essential and much needed nutrients, minerals, and chemicals may also lead to problems to the bones and many more.

The Fanconi syndrome is named after Guido Fanconi, a Swiss who also happens to be a pediatrician. However, there are many debates about to whom the credit must be given to since in reality; Guido Fanconi had never even taken the syndrome as a syndrome and thus, he had failed to identify it as a syndrome. However, it remains unchanged more likely because of the fact that it is already a custom for a syndrome to be named after the first person who had ever made notes about the constellation of signs, symptoms, as well as complications and had identified them occurring all at once or together.

Fanconi Syndrome Symptoms

There are more than six ways for anyone who pays attention to identify if he or she, or even another person has or is suffering from the Fanconi syndrome. A majority of all these signs as well as the symptoms of Fanconi syndrome, however, may require some laboratory tests and a professional consultation from a professional licensed doctor. This is because that this set of symptoms are found and identified in the urine.

Any content of glucose, amino acids, citrate, and phosphate, discovered in a single individual person’s urine could may as well signal that the person has or is suffering from the Fanconi syndrome. Glucose in urine can be identified by a series of observations. Usually, the urine of the person would attract ants due to the content of glucose which is a substance known to attract different kinds of ants.

Another symptom that may also require you to get a laboratory test and another professional consultation from a professional licensed doctor would be the fact that a person who is suffering from the Fanconi syndrome would also experience a thing known as Hypokalemia. Hypokalemia means that a person has low phosphate content in his or her blood.

Now to identify this symptom, a blood test may now be needed. Hypokalemia is caused and triggered because of the fact that when a person has the Fanconi syndrome, he or she would excrete phosphate and thus, be rendered unable to use them resulting in a low content.

Bone deficiencies may also be a very distinctive set of signs as well as symptoms that could mean a person has Fanconi syndrome. This is because of the excretion of substances that are very important so that a person’s bones may remain strong and develop well, easily, and normal. There may also be a deficiency regarding Vitamin D.

Fanconi Syndrome Causes

Fanconi syndrome has many factors that could cause it. First of all it would be very important to emphasize the fact that the Fanconi syndrome can be inherited. Any record of Cystinosis, Wilson’s disease, tyrosinemia, glycogen storage diseases, fructose intolerance, galactosemia, and the Lowe syndrome are also counted as some of the many inherited causes of the Fanconi syndrome.

Other than that, a person may also acquire the Fanconi syndrome later in life by ingesting some expired tetracycline which, like any other substance, is bad for the health when taken in after its expiration. Fanconi syndrome may also be a result due to the use of an antiretroviral regimen which has a tenfovir and didanosine content. Other than that, a monoclonal gammopathy of an unidentified or undetermined significance and lead poisoning alongside multiple myeloma may also lead to the development of the Fanconi syndrome.

Fanconi Syndrome Treatment

Like most of the other syndromes as well as diseases, you’re in luck if you have the Fanconi syndrome, since there are in fact, many different ways to cure and to treat the Fanconi syndrome. But before going on to all that medications and medicines, you will really be very glad to know that you can prevent Fanconi syndrome from happening to you. Dehydration can lead to the syndrome and the way to prevent this is by maintaining a healthy balanced intake of liquids and rehydrate more often.

If you are identified with the other conditions that are also causes of the Fanconi syndrome then you should quickly treat yourself from them so that they would not cause the syndrome. But if you already have the Fanconi syndrome then you may also undergo Alkali therapy in order for you to correct the metabolic acidosis. Vitamin D and phosphate supplements may also be taken and you can also undergo an electrolyte replacement.

But before doing anything at all, it is recommended that you consult a professional doctor first.

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